کتاب های Hernández-Tamames, Juan Antonio; Mato Abad, Virginia; García-Álvarez, Roberto; González-Zabaleta, Javier; Pereira-Loureiro, Javier; Álvarez-Linera, Juan

download pdf Effect of water T2 shortening in the quantification of in-vitro proton MR spectroscopy, دانلود Effect of water T2 shortening in the quantification of in-vitro proton MR spectroscopy,Hernández-Tamames, Juan Antonio; Mato Abad, Virginia; García-Álvarez, Roberto; González-Zabaleta, Javier; Pereira-Loureiro, Javier; Álvarez-Linera, Juan, کتاب های Hernández-Tamames, Juan Antonio; Mato Abad, Virginia; García-Álvarez, Roberto; González-Zabaleta, Javier; Pereira-Loureiro, Javier; Álvarez-Linera, Juan,Wiley 2015-05-21, لیست کتاب های Wiley 2015-05-21,WorldCat, کتاب های WorldCat

گت بلاگز Internet Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty / دانلود فایل

مشخصات کلی Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty

نویسنده کتاب (Author):

Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido Carballido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel

انتشارات (Publisher):

Endocrine Society 2013

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

sangiao-alvarellos-s-manfredi-lozano-m-ruiz-pino-f-et-al-changes-in-hypothalamic-expression-of-the-lin28let-7-system-and-related-micrornas-during-postnatal-maturation-and-after-experimental-manip

توضیحات خلاصه (Summary):

[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable interest has arisen recently concerning other physiological roles of the Lin28/let-7 axis, including its potential involvement in the control of puberty, as suggested by genome-wide association studies and functional genomics. We report herein the expression profiles of Lin28 and let-7 members in the rat hypothalamus during postnatal maturation and in selected models of altered puberty. The expression patterns of c-Myc (upstream positive regulator of Lin28), mir-145 (negative regulator of c-Myc), and mir-132 and mir-9 (putative miRNA repressors of Lin28, predicted by bioinformatic algorithms) were also explored. In male and female rats, Lin28, Lin28b, and c-Myc mRNAs displayed very high hypothalamic expression during the neonatal period, markedly decreased during the infantile-to-juvenile transition and reached minimal levels before/around puberty. A similar puberty-related decline was observed for Lin28b in monkey hypothalamus but not in the rat cortex, suggesting species conservation and tissue specificity. Conversely, let-7a, let-7b, mir-132, and mir-145, but not mir-9, showed opposite expression profiles. Perturbation of brain sex differentiation and puberty, by neonatal treatment with estrogen or androgen, altered the expression ratios of Lin28/let-7 at the time of puberty. Changes in the c-Myc/Lin28b/let-7 pathway were also detected in models of delayed puberty linked to early photoperiod manipulation and, to a lesser extent, postnatal underfeeding or chronic subnutrition. Altogether, our data are the first to document dramatic changes in the expression of the Lin28/let-7 axis in the rat hypothalamus during the postnatal maturation and after different manipulations that disturb puberty, thus suggesting the potential involvement of developmental ch  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido Carballido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel

شناسه OCLC:979265348

Language Note:English

فهرست محتوا:0013-722 1945-7170 http://hdl.handle.net/2183/17559

نویسنده : getblogs